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231 Similarly, miR-21-5p was suggested to potentially induce the epithelial permeability of Caco-2 cells due to the downregulation of ADP ribosylation factor 4, which modulates occludin and CLDN4 abundance
The above issues lead to variability in diagnosis, in monitoring illness severity, in predicting treatment response and in developing targeted therapies for these disorders, in turn highlighting a significant unmet medical need [4,5,6]
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