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Furthermore, mice with blunted IGF-I receptor activity in orexin neurons have lower levels of orexin in the hypothalamus, show altered electrocorticographic patterns with predominant slow wave activity, reduced onset-sleep latency, and less transitions between sleep and awake stages

This limitation can lead to permanent functional impairments affecting speech, sensation, and limb movement, thereby severely impacting patient behavioral and social capabilities (12, 13)

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