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doi: 10.1104/pp.104.045724

When you take pills or oral medicines, it takes time for them to work through your system and into your blood

Phase 2: Days 314 Early Subjective Changes Most research subjects and supervised users begin noticing the first subjective changes in this window: Improved muscle fullness cells are retaining more glycogen and water, creating a pumped appearance Faster workout recovery reduced delayed onset muscle soreness (DOMS), ability to train with greater frequency Increased training capacity subtle improvements in endurance and work output Sleep quality changes some users report deeper sleep, consistent with increased GH axis activity Mild water retention particularly around joints, which can also temporarily ease joint discomfort These early changes are real but modest