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In particular, unlike the conventional method, the method of the present invention can achieve preparation of (R)-4-chloro-3-hydroxy butyric acid alkyl ester having an optical purity of more than 99%ee from the hydrolysis of the racemic 4-chloro-3-hydroxy butyric acid alkyl ester using the enzyme

However, other factors may be involved, including accumulation of lactate, pyruvate, glutamine and free glucose, and depletion of glycogen, ketone bodies and glutamate

Oxidative stress, epigenetic regulation and pathological processes of lens epithelial cells underlying diabetic cataract

Gureev AP, Shaforostova EA, Popov VN