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This may trigger subsequent damage, including lipid peroxidation, cellular degeneration, and the release of diverse regulatory molecules and cytokines that drive the further progression of the disease

Research has shown that NEDD4 expression in the kidney and liver is regulated by 20-hydroxyeicosatetraenoic acid through the neddylation modification pathway [55] and that Nedd4-2 activation regulates the ubiquitination modification of renal NBCe1 [56]

These IB proteins lack their inherent biological activity because they form aggregates and are difficult to purify and refold into their native conformation(s)

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