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The expression of markers was detected by ECL/ECL Prime Western Blotting Detection Reagents (GE Healthcare, Piscataway, NJ, USA) following the manufacturer's instructions
In summary, GLPs regulate systemic glucose homeostasis via a multi-tiered, integrative mechanism: they inhibit excessive hepatic glucose production by downregulating key gluconeogenic enzymes and suppressing glycogenolysis
Daily or weekly administration of pegbelfermin for 12 weeks in type 2 diabetes patients recapitulated these modest effects on lipid parameters without altering body weight, and did not elicit clinically or statistically significant changes in markers of glycemic control (295)
Generation of a proton motive force by the anaerobic oxalate-degrading bacterium Oxalobacter formigenes
