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The restoration of mitochondrial quality in aged tissuesconverting dysfunctional mitochondria back to healthy, efficient energy producersoffers a mechanistic basis for slowing or partially reversing aspects of the aging process

Epitalon works indirectly by regulating the pineal gland and melatonin synthesis, potentially normalizing circadian rhythms

Hydrogendeuterium exchange For hydrogendeuterium exchange experiments, deuterated buffer was prepared by lyophilizing eIF2B assay buffer (20 mM HEPES, 200 mM KCl, 5 mM MgCl 2 and 1 mM TCEP pH 7.9) and resuspending it in deuterium oxide (Sigma-Aldrich, 151882)

Eng C, Bendell JC, Kopetz S , Tarco E, Xiao L, Ying J, Wang X, Phillips J, Sportelli P, Meric-Bernstam F