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This article covers their mechanisms, clinical data, side effect profiles, and which research contexts favour one compound over the other

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The verdict: in most situation, vitamin B12 likely has no effect on hair loss (and hair regrowth), but vitamin B12 might reverse premature hair graying in the presence of B12 deficiency Although hypothetical evidence suggests an absence of B12 activity could negatively impact hair growth, in vivo human studies indicate that either (1) there is no relationship between vitamin B12 deficiency and hair loss and/or (2) there is an overriding factor (like methionine provision outside of the methylation cycle) that prevents B12 deficiency from causing hair loss

The honest research caveat is that "theoretically additive" is not "experimentally additive" and a researcher who needs to claim synergy must run the combination versus the components in their own model