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Analysis of cerebrospinal fluid (CSF) from PD patients by Olivieri et al
The dose 150 mg QD was selected for the registrational study (MOXIe Part 2) because omaveloxolone displayed maximum pharmacodynamic response on most Nrf2-regulated genes (e.g., AST , CK , and GGT ) and mFARS improvement at 160 mg QD among the doses evaluated
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