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Roles of IGF-1, IGF-1R, and IGFBPs in vascular smooth and endothelial cells IGF-1 and IGF-1R are expressed by vascular smooth muscle cells (VSMCs), endothelial cells (ECs), and macrophages (34), and together with different IGFBPs, they are considered significant regulators of atherosclerosis pathophysiology whose expression is downregulated in atherosclerotic lesions (4850)

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