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Furthermore, LDN can influence macrophage polarization, promoting the shift from the pro-inflammatory M1 phenotype (CDR1) towards the restorative M2 phenotype (CDR3), thereby assisting the cell in resolving inflammation and re-entering the repair phase

To address these limitations, advanced drug delivery systems have been developed to enhance therapeutic efficacy while reducing patient burden

Jones and Butler 1975)

Hepatology 77 (4), 12111227
