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The SH-SY5Y cell line has been commonly selected for use in such studies because it is a dopaminergic neuronal cell that can provide insights into a range of neurodegenerative diseases such as Alzheimers, Parkinsons, Huntingtons and amyotrophic lateral sclerosis (ALS)

The authors also stated that the pattern of cellular and protein findings suggests that the brain's own immune system (not immune abnormalities from outside the brain) and the neuroinflammatory process appears to be an ongoing and chronic mechanism of central nervous system (CNS) dysfunction

L-Serine dietary supplementation is associated with clinical improvement of loss-of-function GRIN2B-related pediatric encephalopathy

Alterations in the gut microbiota throughout this time precipitate the onset of chronic disorders such as asthma, allergies, and obesity in both adulthood and childhood (505, 506)