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Throughout the document, comparisons are made with respect to similar liver lesions that may occur in humans

Additionally, medications such as saxagliptin and metformin have demonstrated effectiveness in regulating -cell function by reducing inflammation in newly diagnosed T2DM patients with PCOS (74).These findings suggest that the crucial role of pancreatic inflammation and -cell dysfunction in PCOS-related metabolic complications and highlight the need for targeted interventions that can improve -cell function and reduce inflammation

8,9,10 Here in this review, we highlight those known and yet unexploited key molecular and signaling pathways, particularly the inflammatory, epigenetic, and metabolic aspects that link cell senescence and organismal ageing (Fig

Hassel, 2001