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These include: Allergic reactions, such as hives or trouble breathing Heart problems in people with heart issues Drug Interactions and Contraindications Vitamin B12 shots can affect how some medicines work or have special warnings

it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinsons disease

This minimum requirement becomes the de facto standard