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237,238 Synphilin-1 also significantly decreases p53 expression and transcriptional activity and reduces p53 mRNA levels and p53 promoter transactivation, which are caused mainly by the production of C-terminal products through caspase-3-mediated cleavage

Sibulo , President, McGraw Pharma Inc

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Non-pharmacological approaches involve addressing the underlying causes of cirrhosis and adhering to the validated TrACE (Treating causes, Ameliorating modifiable factors, Coping mechanisms, and Empathizing) model, particularly used to manage fatigue in primary biliary cholangitis