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The gene encoding for leptin is mutated in genetically obese (ob/ob) mice

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bFGF, which is one of the 22 different isotypes of FGF, plays a crucial role in the wound healing process by promoting fibroblast proliferation, inducing neovascularization, and increasing the synthesis of collagenase.3033 As the topical administration of human recombinant bFGF has been shown to be effective for wound healing in clinical situations, we selected bFGF as a positive reagent in this study

And thereby, as assessed also in the recovery course in the rats with the injured/transected tendon, ligament, or muscle [19,20,21,22,31,35,36,37,47], there is with the same therapy background the counteraction of the leg contracture as a reliable, reproducible, and sensitive tool