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The concentration of glutamate is higher, and the accumulation of glutamate can cause neuronal cell toxicity, which indicates that ferroptosis is directly involved in the pathogenesis of ALS mechanism
doi: 10.3390/md18090474
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Artesunate and dihydroartemisinin reduce the voltage-dependent anion channel 1 protein levels and cleavage CASP-3, possibly mediating mitochondrial disruption through ROS (Zhang et al., 2021)
