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Various electrophilic compounds are known to cause intracellular damage by covalently binding to DNA and proteins
Upon entering the cell, MPP+ inhibits the mitochondrial ETC Complex I enzyme, and NADH-ubiquinone oxidoreductase (EC 1.6.5.3), resulting in electron leakage and ROS generation in mitochondria [32]
However, the review authors also noted that further studies are necessary
