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Circannual rhythms of bone marrow cell composition in animals during aging: The role of pineal factors

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Results showed 40% improvement in stress resilience scores and 25% reduction in anxiety-related symptoms over 12-week treatment periods

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The sleep deprivation pro-inflammatory milieu was accompanied by oxidative stress in the brain 137 and BBB disruption with consequent increased permeability to blood components 138

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In perimenopause, hyperactive kisspeptin neurons are now understood to drive vasomotor symptoms hot flushes and night sweats via co-expressed neurokinin B and dynorphin pathways

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