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Circannual rhythms of bone marrow cell composition in animals during aging: The role of pineal factors

Results showed 40% improvement in stress resilience scores and 25% reduction in anxiety-related symptoms over 12-week treatment periods

The sleep deprivation pro-inflammatory milieu was accompanied by oxidative stress in the brain 137 and BBB disruption with consequent increased permeability to blood components 138

In perimenopause, hyperactive kisspeptin neurons are now understood to drive vasomotor symptoms hot flushes and night sweats via co-expressed neurokinin B and dynorphin pathways
