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29 The junctional protein JAM-A is also involved in the barrier function, and decreased JAM-A expression has been reported in IBDs

3.1 Inhibition of NRF2 triggers ferroptosis Among the numerous mechanisms that regulate ferroptosis, NRF2 is a significant regulator of the antioxidant system, and its regulation of SLC7A11 has already been discussed

Vitamin B12 functions in the body through two bioactive coenzymes: Methylcobalamin Functions in the cell plasma as a coenzyme in the methylation cycle Adenosylcobalamin Functions in the mitochondria as a coenzyme in the citric acid cycle Through these two functional mechanisms, multiple effects take place in diverse biological systems as explored in our article: Vitamin B12 Benefits The focus of this article is on methylcobalamin and its working within the methylation cycle

doi: 10.3390/nu9050437 172