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These IDH1/2 mutations result in a gain of function reducing of -ketoglutarate to 2-hydroxyglutarate (2-HG), a competitive inhibitor of KG-dependent dioxygenases like TETs
[DOI] [PubMed] [Google Scholar] Krivic A, Anic T, Seiwerth S, Huljev D, Sikiric P
An example would be a common chemotherapy for colon cancer called 5-fu (5-fluorouracil) and the integrative therapy would be curcumin- Those two therapies are examples but there are others
Hydration: Keep your skin well-hydrated and moisturized
