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When organelles such as mitochondria, endoplasmic reticula (ER), and peroxisomes are damaged and dysfunctional, more ROS are produced [1, 18] in a vicious cycle [14, 24]

Cell 176:98112 Gokul G, Khosla S (2012) DNA methylation and cancer

was supported by USDA NIFA postdoctoral fellowship, grant #2020-67034-31780/project accession#1022959

Faber PW, Alter JR, MacDonald ME, Hart AC
