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Consensus NFB, Sp-1, AP-1, activator protein-2 (AP-2), metal response (MRE), and antioxidant response (ARE)/electrophile responsive (EpRE) elements have been identified in the human GCLC promoter

In those patients neurological symptoms and damage are the key to diagnosis

Vomiting occurred in 12 (28%) patients and was more frequently reported by patients 5 to 10 years of age compared to patients 11 to 17 years of age (50% and 9% of patients, respectively)
