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This pattern has largely been reproduced in many, although not all, studies in non-human primates using different SHIVs, different nAbs and different challenge routes 12

The acetyl-CoA enters the Krebs cycle and together with oxaloacetate give rise to citrate, which can be exported to the cytoplasm and engage in NADPH-producing reactions: the transformation of malate to pyruvate catalyzed by malic enzyme (ME1) and the oxidation of isocitrate into -ketoglutarate catalyzed by isocitrate dehydrogenase (IDH1)

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Phase 1/2 study of the safety and tolerability of nivolumab plus crizotinib for the first-line treatment of anaplastic lymphoma kinase translocationpositive advanced non-small cell lung cancer (CheckMate 370)