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Increased circulating C3a levels during pregnancy are a critical biomarker not only for preeclampsia prediction but also for depression during pregnancy, as the Edinburgh postnatal depression scale (EPDS) alone is not perfectly sufficient to detect major depressive disorder during pregnancy (495)

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However, the overall impact of necroptosis on tumor progression therefore depends critically on contextual factors, including the intensity and duration of RIPK3MLKL activation, the specific cell types undergoing necroptosis, and the composition of the tumor microenvironment (11)

However, studies of hirudin are currently limited by small sample sizes and insufficient standardization of experimental design, resulting in an optimal therapeutic window and long-term safety of the drug that remain to be clarified