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GSH, present at ~2 mmol/L in the RBC, not only supports antioxidant defenses but also is an important sulfhydryl buffer, maintaining SH groups in hemoglobin and enzymes in the reduced state

proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36

Besides, the disturbing neural output of the cochlea could partly be implicated in their dysfunction

Gastroenterology 146(6):14891499 Kraft V, Bezjian CT, Pfeiffer S, Ringelstetter L, Mller C, Zandkarimi F, Merl-Pham J, Bao X, Anastasov N, Kssl J (2019) GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling