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The canonical NF-B signaling can be activated by a wide range of stimuli such as ROS, inflammatory cytokines (e.g., tumor necrosis factor-alpha (TNF-), interleukin (IL)-6, and IL-1), growth factors, radiations, infections, and oncogenic stresses and is in turn responsible for the activation of the NLRP3 inflammasome and the transcriptional induction of pro-inflammatory cytokines (pro-IL-1 and pro-IL-18, converted to mature forms by caspase-1, one of the NLRP3 components) and chemokines (TNF-) [130]

they also have no distinct odor and do not change the organoleptic properties of meals [12]

[DOI] [PubMed] [Google Scholar] 452.Dringen R, Pfeiffer B, Hamprecht B

For example, certain gut microbes may affect hormone levels in the thyroid gland by producing metabolites that affect hormone synthesis or metabolism (Liu X