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No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen

Other studies found that TMAO induces hypercholesterolemia by promoting intracellular CHO accumulationenhancing macrophage cholesterol accumulation via microbiota-dependent pathways involving the increased expression of pro-atherogenic scavenger receptor proteins CD36 and SRA on the cell surface (Wang et al., 2011)

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The composition of the tea varies depending on the fermentation process employed to produce it