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Description
Acetaldehyde further compromises the ER by modifying chaperones and enzymes, interfering with disulfide bond formation and glycosylation, depleting glutathione, disturbing calcium signaling, and causing homocysteine accumulation ( Alcohol and endogenous aldehydes also cause DNA double-strand breaks and chromosomal rearrangements in hematopoietic stem cells

Ji, Y., Wang, T., Wei, Z.-F., Lu, G.-X., Xia, Y.-F., & Dai, Y

Oct 1990;177(1):121-5

doi: 10.1111/j.1742-4658.2006.05136.x
