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Other studies developed its application as a laboratory reagent to probe peptidemediated signaling process related to tissue homeostasis, angiogenic signaling, and cellular stress response in vitro/ preclinical conditions

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Mitochondrial Resilience and Energy Homeostasis By stimulating AMPK and NRF2 pathways, MOTS-C peptide helps maintain mitochondrial function under stress

The major efficacy outcome measure was overall survival and additional efficacy outcome measures were time to disease progression, overall response rate, and response duration