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Irrespective, the TJ did not appear to be affected morphologically in these mice (of either sex) and the barrier function of the intestinal epithelium (small and large intestine), based on electrophysiological measurements, also appeared normal
Increased liver enzyme levels were observed in clinical trials, raising concern for hepatotoxicity with long-term use of SARMs Narayanan et al., Therapeutic Advances in Endocrinology and Metabolism 3
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10.1016/J.EJPHAR.2018.11.007 16 DavieN.HaleenS.UptonP.PolakJ.YacoubM.MorrellN.et al (2002)
