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An integrative use of in vitro BBB models and in vivo techniques, together with advances in medicinal chemistry and tailor-made design of antibodies, proteins and peptides, are likely to be of key importance

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Hence it is likely that the resting state in GluK3 with the LBDs coupled as two dimers may not be as stable as in AMPA and kainate receptors of known structures

One canonical way for -KG to regulate gene transcription is to act as an epigenetic cofactor for Fe 2+ -dependent and 2-oxoglutarate-dependent dioxygenases (2OGDDs), including TET DNA demethylases and Jumonji C domain-containing histone demethylases (JMJD3 and UTX) 16,42,43