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Recent advances highlight their potential in cancer immunotherapy, exemplified by Moderna's KRAS mRNA vaccine (NCT03948763) currently under clinical evaluation for solid tumors, as well as other tumorassociated antigen (TAA)targeted mRNA vaccines entering earlyphase oncology trials [5]

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Numerous studies have shown polyphenolic compounds to alleviate gene mutations and the onset of degenerative diseases by combating oxidative stress, thereby mitigating the inflammatory microenvironment [143, 144]