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Hoffman, J

doi: 10.3389/fphar.2025.1591825 Received 11 March 2025 Accepted 28 August 2025 Published 08 October 2025 Volume 16 - 2025 Edited by Er Sheng Gong, Gannan Medical University, China Reviewed by Guillermo Federico Spitzmaul, National Scientific and Technical Research Council (CONICET), Argentina Leonardo Dionisio, National Scientific and Technical Research Council (CONICET), Argentina Updates Copyright 2025 Giannini, Soldi, Elli, Sagheddu, Castagnetti, Viciani, Salvini, Battistuzzi, Milazzo, Alibrandi and Sidoti

Insulin, which is secreted by islet cells, and glucagon, which is secreted by islet cells, are the key hormones that regulate blood glucose homeostasis [55], and the ratio of these two hormones is closely related to glucose homeostasis

[10] [11] A phase II clinical trial on the efficacy and safety of meldonium for acute ischemic stroke was completed in August 2013 and the studies showed that meldonium is as effective and safe as cinepazide injection