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doi: 10.1016/j.ejphar.2007.05.072

The recommended dosage of Pemetrexed Injection for maintenance treatment of non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity after four cycles of platinum based first-line chemotherapy

In view of the pivotal role that macrophage polarization plays in the context of liver inflammation, there is a clear necessity for further research in this area to be conducted