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For example, human chest wall skeletal muscle arterioles taken from diabetic patients exhibited decreased contractile responses to endothelin-1 ( 4 A deeper look: PKC and endothelial dysfunction in diabetic nephropathy Diabetic nephropathy is a serious long term microvascular complication of T1 and T2 diabetes that occurs in 20%40% of diabetic patients ( On a basic level, PKC may directly blunt insulin signaling in diabetic glomeruli