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Because the DECR1 encoded enzyme is localized to the mitochondria and requires NADPH as a co-factor
Approximately 95% of total body carnitine is stored in heart and skeletal muscle, with the remainder in the liver, kidneys, and circulating plasma [1][4]
RCS levels can be used as a biomarker to identify the severity of diabetic complications, as RCS levels correlate with the severity of organ damage in diabetic patients (Dham et al., 2021)
