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922 In AKT-hyperactivated cancer cells, AKT directly phosphorylates the Ser343 site of TRPML1, inhibits the K552 ubiquitination degradation of TRPML1, and promotes the binding of TRPML1 to ARL8B, leading to lysosomal exocytosis

The strong correlation between serum ferritin and IR parameters in our MASLD cohort, coupled with the metabolic improvements observed following iron chelation in our mouse model, suggests that stratifying patients on the basis of iron status could help identify those most likely to benefit from iron-targeted interventions

doi: 10.1006/bbrc.1997.6878

tb in macrophages of patients infected with HIV