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Folic acid deficiency can also be triggered by regular dialysis treatment, drug-based cancer treatment, chronic diarrhea, overactive thyroid, and genetic defects of folic acid metabolism
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According to a 2017 meta-analysis published in PLoS One, lower urinary iodine concentration levels are linked to a higher risk of goiter, and iodine deficiency may increase the risk of goiter ( 9 )
Additionally, Nrf2 is directly regulated by the circadian transcription factor BMAL1, particularly in lung and pancreatic tissues (Pekovic-Vaughan et al., 2014)
