is biologically active glutathione oxidized or reduced Glutathione/Glutaredoxin in Cellular Redox Homeostasis and Signaling The Multifaceted Role of Glutathione

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In stressed neutrophils, during an oxidative burst, glycolysis is shifted to the PPP, allowing the neutrophils to promptly mount a first line of defense against pathogens, using the generated NADPH for redox signaling ( 5.1.4 Oxidative phosphorylation Despite possessing intact mitochondria and a functional TCA cycle, mature neutrophils exhibit minimal reliance on mitochondrial respiration for their energy production (Rodrguez-Espinosa et al., 2015), since the inhibition of mitochondrial respiration had no impact on ATP generation in mature neutrophils (Maianski et al., 2004)

Zhou Y, Geng Z, Wang X, et al