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Moreover, acetate and butyrate decrease the levels of reactive oxygen species (ROS), enhance the secretion of anti-inflammatory cytokine IL-10 and immunoregulatory factor IFN-, thereby further mitigating the inflammatory response (68)

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Experimental models of bone defects have shown that, when SVVYGLR was implanted together with a collagen sponge, an upregulation of osteogenesis and angiogenesis was observed [169, 239]

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