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Acknowledgements This research was supported by the National Key R&D Program of China (2024YFA1212500), the National Natural Science Foundation of China projects (32171320 and 82302384), the Key Project of the Natural Science Foundation of Shaanxi Province (2025JC-QYCX-066), the National University of Singapore (NUHSRO/2020/133/Startup/08, NUHSRO/2023/008/NUSMed/TCE/LOA, NUHSRO/2021/034/TRP/09/Nanomedicine, 23-0173-A0001), the National Medical Research Council (MOH-001388-00, CG21APR1005, OFIRG23jul-0047), the National Research Foundation (NRF-000352-00), and start-up funding from Shandong Cancer Hospital (rcyj-202603) Ethics declarations Competing interests The authors declare no competing interests

METHODOLOGY The principal method now employed for the detection of porphyrins in biological materials in the clinical laboratory is based on the characteristic red fluorescence observed when acidic solutions of the porphyrins are exposed to ultraviolet light

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Fast computation of full density matrix of multispin systems for spatially localized in vivo magnetic resonance spectroscopy: Med Phys