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PharmaTimes, 04/2011

For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc (Sxc ), present in astrocytes, and EAAT3 present in neurons

These mechanisms have been studied predominantly in in vitro cell culture models and animal research models

While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown