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A good example would be the backs of the hands of a fair individual who has been exposed to the sun over many years
The secret sauce is something only Professor Bader (creator of the original eponymous brand) and Lipa could have cooked up together: TFC5

For example, a mutation in CACNA causes enhanced glutaminergic transmission because it allows the channels to open at more hyperpolarized membrane potentials than usual, which causes a more significant calcium influx to the terminal during the action potential

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