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Introduction The human brain represents approximately 2% of total body weight and receives up to 15% of total blood flow, consuming up to 20% of oxygen and 25% of circulating glucose under normal conditions (Pellerin, 2010)

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Table 4 represents the most frequently reported postmarketing adverse reactions as MedDRA Preferred Terms

Additionally, the oxidation status of peroxiredoxin 1 (PRDX1), a direct substrate of TRX, was tested by employing a redox western blot to reflect the activity of TXNRD1 indirectly