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This finding demonstrates that dietary l-serine supplementation can override genetically induced SPT promiscuity to restore sphingolipid diversity and clinical outcomes in HSAN1 patients

, Mupere, E

Knockout of Rnf213 ameliorates cerebral ischemic-reperfusion injury by inhibiting neuronal apoptosis through the Akt/GSK-3beta/beta-catenin/Bcl-2 pathway

Furthermore, inhibiting TLR4 can also modulate gut microbiota homeostasis and the MyD88/NF-B axis in ulcerative colitis (164), indicating that TLR4 acts not only as a key sensor of innate immunity but may also regulate neuroimmune crosstalk and gut microenvironment homeostasis