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Membrane melatonin G-protein coupled receptors are common on many, perhaps all, cells (155158) and when they bind melatonin, the activities of several antioxidative enzymes are stimulated, including SOD, GPx, glutathione reductase (GRd), CAT, and glutamate cysteine ligase (GCL), the rate limiting enzyme in glutathione production (21, 159, 160)

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Some also turn to GH