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The reasonable reading is that cagrilintides gastrointestinal effects are mechanism-based and generally manageable with titration in the studied populations, but that manageable in trials is not the same as fully characterized for long-term real-world use, and the delayed-emptying mechanism itself carries context-specific cautions that should not be waved away
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[56] Serum haptocorrin binds 80-90% of circulating B 12 , rendering it unavailable for cellular delivery by transcobalamin II
