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Colonic Contribution to Uremic Solutes

an L-carnitine calcium salt of the present invention is soluble in water and aqueous solutions (such as those found in the stomach and intestine) the inventors expect that ingestion of a dosage form containing an L-carnitine calcium salt of an organic acid of the present invention by a subject will beneficially increase the plasma and red blood cell carnitine concentrations and the free/total carnitine ratios

Both have a long history of use as dietary supplements

Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine