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Current Pharmaceutical Design , 24(18), 19902001

The peptides were analyzed by data-dependent acquisition (DDA) in positive mode using Orbitrap MS analyzer for precursor scan at 120,000 FWHM from 400 to 2000 m/z and ion-trap MS analyzer for MS/MS scans in top speed mode (3-s cycle time) with dynamic exclusion settings (repeat count one and exclusion duration 15 s)

Studied in oxidative stress, antioxidant response, cellular defense, and glutathione-dependent pathway models

A therapeutic strategy combining conventional and epigenetic drugs may effectively reduce tumor size while preventing the development of genetic resistance to targeted therapies [29, 30]